abstract：:Bag-1 is an antiapoptotic protein with its altered expression and localization in malignancies. To clarify the role of Bag-1 in gastric carcinogenesis, its expression was examined by immunohistochemistry and in situ hybridization on a tissue microarray containing gastric carcinomas, adjacent nonneoplastic mucosa (NNM)...

journal_title：Human pathology

authors： Zheng HC,Xu XY,Xing YN,Wei ZL,Takahashi H,Masuda S,Takano Y

更新日期：2010-05-01 00:00:00

abstract：:Mesenchymal chondrosarcoma, a rare malignant round cell and hyaline cartilage tumor, is most commonly intraosseous but can occur in extraskeletal sites. We intensively observed the morphology and applied Sox9 (master regulator of chondrogenesis), beta-catenin (involved in bone formation, thought to inhibit chondrogene...

journal_title：Human pathology

authors： Fanburg-Smith JC,Auerbach A,Marwaha JS,Wang Z,Rushing EJ

更新日期：2010-05-01 00:00:00

abstract：:Metastatic cystic squamous cell carcinomas of the neck often harbor human papillomavirus 16 and, in turn, overexpress p16. P16 immunohistochemistry could be useful in the evaluation of patients who present with cystic squamous lesions of the neck, particularly when the distinction between a benign lymphoepithelial cys...

journal_title：Human pathology

authors： Cao D,Begum S,Ali SZ,Westra WH

更新日期：2010-04-01 00:00:00

abstract：:Four cases of large cell calcifying Sertoli cell tumor, 3 benign and 1 malignant, with no clinical signs of Carney complex or Peutz-Jeghers syndrome are reported with results of histologic, immunohistochemical, ultrastructural, and comparative genomic hybridization studies. Analysis of PRKAR1A gene was performed on 2 ...

journal_title：Human pathology

authors： Petersson F,Bulimbasic S,Sima R,Michal M,Hora M,Malagon HD,Matoska J,Hes O

更新日期：2010-04-01 00:00:00

abstract：:Patients undergoing treatment of acute lymphoblastic leukemia are at risk for fungal infections including disseminated candidiasis. We describe a case of systemic Candida albicans infection associated with life-threatening gastrointestinal hemorrhage due to unusual necrotizing vasculitis involving the gastrointestinal...

journal_title：Human pathology

authors： Sargent J,O'Marcaigh A,Smith O,Butler K,Gavin P,O'Sullivan M

更新日期：2010-04-01 00:00:00

abstract：:Most human papillomavirus-associated squamous intraepithelial lesions of the uterine cervix are flat; some have papillary architecture that shows a spectrum of differentiation from low-grade squamous intraepithelial lesions to high-grade squamous intraepithelial lesions. For this subset of lesions, there are few data ...

journal_title：Human pathology

authors： Liang CW,Lin MC,Hsiao CH,Lin YT,Kuo KT

更新日期：2010-03-01 00:00:00

abstract：:A century or so ago, pediatrics and pediatric pathology did not exist. Then, many fetuses/newborns died in utero or shortly after birth. With time, the issue of sepsis was addressed, and a greater number of newborns survived. Gradually, in this soil, the disciplines of pediatrics and pediatric nursing arose, as some r...

journal_title：Human pathology

authors： Nezelof C,Seemayer TA,Bridge JA

更新日期：2010-03-01 00:00:00

abstract：:Encapsulated thyroid tumors of follicular cell origin with high-grade features (EFHG) are unusual neoplasms. In current classification schemes, they are called atypical adenomas or follicular, papillary, or poorly differentiated carcinoma. When noninvasive, EFHG create a major therapeutic/diagnostic dilemma stemming f...

journal_title：Human pathology

authors： Rivera M,Ricarte-Filho J,Patel S,Tuttle M,Shaha A,Shah JP,Fagin JA,Ghossein RA

更新日期：2010-02-01 00:00:00

abstract：:Germ cell tumors arising within the central nervous system are rare neoplasms that typically occur along midline structures in children and young adults. Although isochromosome 12p is established as a frequent chromosomal abnormality in testicular germ cell tumors, studies examining isochromosome 12p in primary centra...

journal_title：Human pathology

authors： Sukov WR,Cheville JC,Giannini C,Carlson AW,Shearer BM,Sinnwell JP,Ketterling RP

更新日期：2010-02-01 00:00:00

abstract：:Nested urothelial carcinoma (UC) is a rare histologic variant of UC, characterized by deceptively bland histologic features resembling von Brunn's nests but usually with a poor outcome. In our experience, this variant is frequently misclassified or underrecognized as its clinicopathologic spectrum is not well defined....

journal_title：Human pathology

authors： Wasco MJ,Daignault S,Bradley D,Shah RB

更新日期：2010-02-01 00:00:00

abstract：:Prostate-specific membrane antigen (PSMA), a type II transmembrane metallo-peptidase highly overexpressed in prostate cancer cells, has been studied as a targeting molecule in prostate cancer. Recently, PSMA has also been found to be expressed in the neovasculature of multiple nonprostatic solid tumors. Because of its...

journal_title：Human pathology

authors： Haffner MC,Kronberger IE,Ross JS,Sheehan CE,Zitt M,Mühlmann G,Ofner D,Zelger B,Ensinger C,Yang XJ,Geley S,Margreiter R,Bander NH

更新日期：2009-12-01 00:00:00

abstract：:Metallothionein is a group of small molecular weight cysteine-rich proteins with a broad variety of functions. Metallothionein has been shown to regulate apoptosis and proliferation. Overexpression of metallothionein frequently occurs in human tumors and is related to prognosis as well as therapy response. However, me...

journal_title：Human pathology

authors： Schmitz KJ,Lang H,Kaiser G,Wohlschlaeger J,Sotiropoulos GC,Baba HA,Jasani B,Schmid KW

更新日期：2009-12-01 00:00:00

abstract：:IMP3, an oncofetal protein, is a member of the insulin-like growth factor-II (IGF-II) mRNA-binding protein family. Its relevance as a novel biomarker in lung, pancreatic, renal, and cervical adenocarcinoma was recently revealed. However, its role in breast carcinogenesis and tumor progression is not yet established. B...

journal_title：Human pathology

authors： Walter O,Prasad M,Lu S,Quinlan RM,Edmiston KL,Khan A

更新日期：2009-11-01 00:00:00

abstract：:A total of 50 neuroblastomas were assessed for frequency of ALK gene copy number aberrations by interphase fluorescence in situ hybridization using a break-apart fluorescence in situ hybridization probe. The data were compared with status of MYCN, 11q, 17q, and 1p36. We observed ALK aberrations (amplification, 1 of 45...

journal_title：Human pathology

authors： Subramaniam MM,Piqueras M,Navarro S,Noguera R

更新日期：2009-11-01 00:00:00

abstract：:Diffuse gastric cancer, characterized by poorly cohesive, diffusely infiltrating cells with no or little gland formation, is known to show several morphologic variants, but their prognostic value, if any, is poorly documented. In this article, 119 cases of invasive (T1b to T4) diffuse gastric cancer, which had undergo...

journal_title：Human pathology

authors： Chiaravalli AM,Klersy C,Tava F,Manca R,Fiocca R,Capella C,Solcia E

更新日期：2009-11-01 00:00:00

abstract：:Gene hypomethylation and hypermethylation can lead to a loss of genetic imprinting in malignancies. The mechanism responsible for overexpression of the imprinted insulin-like growth factor II (IGF2) gene has not been investigated in osteosarcoma. In this study, the expression levels, imprinting status, and the extent ...

journal_title：Human pathology

authors： Li Y,Meng G,Huang L,Guo QN

更新日期：2009-10-01 00:00:00

abstract：:A distinctive variant of basal cell adenoma called membranous basal cell adenoma is well recognized in salivary glands. It appears identical to cutaneous cylindroma, hence the synonym dermal analogue tumor. We present a case of a tumor involving the parotid gland that appeared identical to cutaneous spiradenoma. In ad...

journal_title：Human pathology

authors： Kazakov DV,Benkova K,Michal M,Vanecek T,Kacerovska D,Skalova A

更新日期：2009-10-01 00:00:00

abstract：:In this review we summarize recent advances in the histopathological diagnostic criteria and molecular pathology of the main subtypes of ovarian surface epithelial carcinoma. These advances have greatly improved our understanding of the biology of ovarian carcinoma and are also relevant to patient management. With pro...

journal_title：Human pathology

authors： Gilks CB,Prat J

更新日期：2009-09-01 00:00:00

abstract：:Neoplasms consisting of pituitary adenoma and craniopharyngioma components are rare and are being increasingly recognized. Their histogenesis is not clear. Most represent collision tumors; others are difficult to assess. Here, we describe a pituitary adenoma with an intermingled craniopharyngioma component, without fo...

journal_title：Human pathology

authors： Gokden M,Mrak RE

更新日期：2009-08-01 00:00:00

abstract：:An increase in S100 protein-positive cells has been reported in inflammatory bowel diseases, mainly Crohn disease. These cells were interpreted as myeloid-derived dendritic cells, chiefly in follicular areas. We were prompted to assess the nature of these cells in interfollicular areas of inflamed colonic mucosa in ul...

journal_title：Human pathology

authors： Mosnier JF,Jarry A,Camdessanché JP,Antoine JC,Laboisse CL

更新日期：2009-08-01 00:00:00

abstract：:Recently, the fusion gene EML4-ALK was identified in non-small cell lung carcinoma, which could be a potential therapeutic target. We investigated the prevalence of anaplastic lymphoma kinase protein expression in these tumors by immunohistochemistry and correlated the results with data from ALK molecular studies. Gen...

journal_title：Human pathology

authors： Boland JM,Erdogan S,Vasmatzis G,Yang P,Tillmans LS,Johnson MR,Wang X,Peterson LM,Halling KC,Oliveira AM,Aubry MC,Yi ES

更新日期：2009-08-01 00:00:00

abstract：:Cervical carcinoma is the most common cancer among Belizean women; however, data regarding the frequency of human papillomavirus (HPV) genotypes and their association with cervical cancer are nonexistent. We therefore included HPV genotyping as part of a week-long cervical cancer screening campaign conducted in Belize...

journal_title：Human pathology

authors： Cathro HP,Loya T,Dominguez F,Howe SL,Howell R,Orndorff K,Moreno J,Mendez E,Fung PC,Beer NL,Allen P,Sosa AM,Gurka KK,Stoler MH,Frierson HF Jr

更新日期：2009-07-01 00:00:00

abstract：:Rosette-forming glioneuronal tumors of the fourth ventricle are rare brain tumors, and only 19 such lesions have been previously reported. This report presents the first case of a rosette-forming glioneuronal tumors arising from the spinal cord. A 44-year-old woman presented with a 15-year history of dissociated senso...

journal_title：Human pathology

authors： Anan M,Inoue R,Ishii K,Abe T,Fujiki M,Kobayashi H,Goya T,Nakazato Y

更新日期：2009-06-01 00:00:00

abstract：:Mucoepidermoid carcinoma of the breast is a rare entity with specific morphologic and immunohistochemical features similar to its salivary gland counterpart. In the 28 reported cases to date, there has not been a comparison of the molecular characteristics of this tumor with salivary gland mucoepidermoid carcinomas. H...

journal_title：Human pathology

authors： Camelo-Piragua SI,Habib C,Kanumuri P,Lago CE,Mason HS,Otis CN

更新日期：2009-06-01 00:00:00

abstract：:Mucosal addressin cell adhesion molecule 1, expressed on gut endothelial cells, in conjunction with integrin alpha(4)beta(7), expressed on lymphocytes, is critical in lymphocyte homing to the gut. The mucosal addressin cell adhesion molecule 1/integrin alpha(4)beta(7) pathway is involved in the pathogenesis of chronic...

journal_title：Human pathology

authors： Di Sabatino A,Rovedatti L,Rosado MM,Carsetti R,Corazza GR,MacDonald TT

更新日期：2009-05-01 00:00:00

abstract：:To better represent the Gleason score of radical prostatectomy, the International Society of Urologic Pathologists Consensus Committee recommends assigning individual Gleason scores to prostate cancer cores submitted in separate containers and/or multiple cores in the same container with site identifiers. However, sce...

journal_title：Human pathology

authors： Kunju LP,Daignault S,Wei JT,Shah RB

更新日期：2009-04-01 00:00:00

abstract：:Glial tumors of the retina are rare. Most are syndrome associated and include pilocytic astrocytoma in neurofibromatosis type 1 and subependymal giant cell astrocytoma in tuberous sclerosis complex. Acquired, more conventional, diffuse astrocytomas are less frequent. Ependymoma is exquisitely rare. Herein, we report t...

journal_title：Human pathology

authors： Tay A,Scheithauer BW,Cameron JD,Myhre MJ,Boerner MJ

更新日期：2009-04-01 00:00:00

abstract：:Gastrointestinal stromal tumors are a group of mesenchymal tumors arising from the wall of the gastrointestinal tract that are characterized by activating mutations in KIT or PDGFRA. Their proper recognition is important clinically because of their potential responsiveness to targeted therapies. We report a case of du...

journal_title：Human pathology

authors： Adamiak A,Lee CH,Nielsen TO,Webber D,O'Connell JX

更新日期：2009-04-01 00:00:00

abstract：:A recent publication described 5 unusual clear cell renal tumors with prominent smooth muscle stroma that were characterized only by immunostaining. We report 3 additional tumors composed of clear cell renal cell carcinoma intimately admixed with abundant smooth muscle stroma. Epithelial differentiation of the maligna...

journal_title：Human pathology

authors： Shannon BA,Cohen RJ,Segal A,Baker EG,Murch AR

更新日期：2009-03-01 00:00:00

abstract：:(90)Yttrium (Therasphere) microspheres administered via hepatic artery are a valuable option for treatment of hepatocellular carcinoma. This therapy targets tumor nodules while largely sparing hepatic parenchyma. This retrospective study examines liver explants from 13 adult patients with hepatocellular carcinoma who ...

journal_title：Human pathology

authors： Nalesnik MA,Federle M,Buck D,Fontes P,Carr BI

更新日期：2009-01-01 00:00:00

abstract：:The intraoperative diagnosis of pulmonary neuroendocrine tumors can be difficult. Frozen section diagnosis was requested on 87 neuroendocrine tumors including 58 typical carcinoids, 8 atypical carcinoids, 18 large cell neuroendocrine carcinomas, and 3 small cell carcinomas from 2405 patients that underwent frozen sect...

journal_title：Human pathology

authors： Gupta R,Dastane A,McKenna RJ Jr,Marchevsky AM

更新日期：2009-01-01 00:00:00

abstract：:The natural history of pediatric nonalcoholic steatohepatitis is still unknown; however, there are differences between adult and pediatric presentation. Apoptosis may play an important role in pathophysiologic pathways involved in liver damage and progression. Our aim was to detect early apoptosis markers, activated c...

journal_title：Human pathology

authors： Valva P,De Matteo E,Galoppo M,Pedreira A,Giacove G,Lezama C,Marco I,Galoppo MC,Preciado MV

更新日期：2008-12-01 00:00:00

abstract：:T3 renal cell carcinoma (RCC) is a heterogeneous group of tumors that are substaged based on perirenal or sinus fat invasion, adrenal invasion, and renal vein invasion. To evaluate whether the extent of fat invasion (minimal versus extensive) and direct adrenal gland invasion, renal vein invasion with or without concu...

journal_title：Human pathology

authors： Jung SJ,Ro JY,Truong LD,Ayala AG,Shen SS

更新日期：2008-11-01 00:00:00

abstract：:Gene expression studies have identified a basal phenotype of breast cancer; these are hormone receptor and HER2-negative cancers with poor prognosis. High levels of cyclin E and Skp2, and low levels of p27 have previously been individually associated with both basal-like breast cancer and a poor outcome after diagnosi...

journal_title：Human pathology

authors： Voduc D,Nielsen TO,Cheang MC,Foulkes WD

更新日期：2008-10-01 00:00:00

abstract：:Digitization of glass slides holds great promise for increasing workflow efficiency, but current applications have not gained widespread acceptance. Applications to date have not taken into consideration pathologists' workflow patterns, and as a result many find navigation cumbersome and interpretation more challengin...

journal_title：Human pathology

authors： Velez N,Jukic D,Ho J

更新日期：2008-09-01 00:00:00

abstract：:Carbonic anhydrase IX (CA9) is reportedly overexpressed in several types of carcinomas, but little is known about the expression pattern of CA9 in oral cavity cancer and the corresponding normal tissues. We aimed to assess the prevalence of CA9 expression and its prognostic implications in patients with oral cavity sq...

journal_title：Human pathology

authors： Choi SW,Kim JY,Park JY,Cha IH,Kim J,Lee S

更新日期：2008-09-01 00:00:00

abstract：:In retinoblastoma, genetic alteration of N-myc amplification different from the alteration of the RB1 gene on chromosome 13q14 has been described. This study is to determine the frequency of N-myc amplification by fluorescence in situ hybridization method in retinoblastoma. This study was prospectively derived from 26...

journal_title：Human pathology

authors： Kim JH,Choi JM,Yu YS,Kim DH,Kim JH,Kim KW

更新日期：2008-08-01 00:00:00

abstract：:Atrial fibrillation becomes a self-perpetuating arrhythmia as a consequence of electrophysiologic and structural remodeling involving the atrium. Oxidative stress may be a link between this rhythm disturbance and electrophysiologic remodeling. The aim of this study was to evaluate whether the heme oxygenase-1 (HO-1) m...

journal_title：Human pathology

authors： Corradi D,Callegari S,Maestri R,Benussi S,Bosio S,De Palma G,Alinovi R,Caglieri A,Goldoni M,Mozzoni P,Pastori P,Manotti L,Nascimbene S,Dorigo E,Rusconi R,Astorri E,Alfieri O

更新日期：2008-08-01 00:00:00

abstract：:Ovarian surface epithelial carcinomas are routinely subclassified by pathologists based on tumor cell type and grade. It is controversial whether cell type or grade is superior in predicting patient response to treatment or survival, in patients stratified by stage of disease. The aim of this study was to uniformly ap...

journal_title：Human pathology

authors： Gilks CB,Ionescu DN,Kalloger SE,Köbel M,Irving J,Clarke B,Santos J,Le N,Moravan V,Swenerton K,Cheryl Brown Ovarian Cancer Outcomes Unit of the British Columbia Cancer Agency.

更新日期：2008-08-01 00:00:00

abstract：:Cholangiocarcinoma of intrahepatic and extrahepatic bile ducts has a multistep carcinogenesis. Two premalignant lesions have been suggested for invasive cholangiocarcinoma: biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct. How the carcinogenetic process differs between biliary intr...

journal_title：Human pathology

authors： Nakanishi Y,Zen Y,Kondo S,Itoh T,Itatsu K,Nakanuma Y

更新日期：2008-08-01 00:00:00